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The choice between methylcobalamin and hydroxocobalamin may depend on factors such as the underlying cause of the deficiency, the preferred route of administration, and individual response to treatment

For GI applications, some practitioners recommend oral administration to maximize local gastrointestinal exposure

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PMID: 6519203 Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity

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