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Finally, we examined the various mechanisms by which acquired hypothyroidism can lead to depression

Thyroid hormone resistance has been associated with higher incidences of obesity, metabolic syndrome, and diabetes, as well as a higher incidence of diabetic complications

J., Seim H

, reperfusion) leading to a burst of ROS generation, termed reductive stress (27)

Programmed cell death, encompassing apoptosis, ferroptosis, necrotic apoptosis and autophagy, is instigated by a series of intracellular processes (101)

Although these disorders are very rare, they underscore the fundamental link between disrupted glutathione homeostasis and pyroglutamate accumulation [75]