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In this B12 article, I am focusing on the vitamin itself, because it deserves dedicated treatment given how commonly it is deficient in post-weight-loss patients and how significant the consequences of that deficiency can be

Use raw HR for this calculation, not placebo-subtracted (placebo arm shows real cardiovascular adaptation from weight loss + lifestyle counseling, so subtraction over-corrects for drug-attributable cost)

You take them with your food, and they digest the fat, protein, and carbs right in your stomach, allowing your healthy intestine to absorb them

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