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Positive results across the board might sound encouraging until you look at the actual effect sizes

Curcumin exhibits biphasic dose-response characteristics, where low doses are beneficial but higher doses may lead to toxicity or reduced efficacy ( Enhancing the bioavailability and stability of curcumin has become a major focus in curcumin research and is fundamental to the development of curcumin-related formulations

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Vitamin C Acts as a cofactor for hydroxylase enzymes that cross-link collagen fibers, strengthens dermal structure, and neutralizes UV-induced oxidative damage to skin cells

Genotoxic and epigenetic mechanisms in arsenic carcinogenicity