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Vitamin C helps regenerate other antioxidants, especially glutathione, which makes it one of the more accessible, natural ways to boost glutathione levels through diet and supplementation

Coffee scrubs can exfoliate and improve circulation but dont go deep enough to tackle stubborn pigmentation

Additionally, the accumulation of GSSG and depletion of GSH can be directly toxic to cells by activating the SAPK/MAPK apoptotic signaling pathway, which leads to programmed cell death [29,83,98,99]

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Glutathione's antioxidant properties extend beyond skin brightening to support DNA repair and protein synthesis

Acknowledgements We thank all the members in State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, and China Agricultural University, for their help in investigating the changes in wool phenotype