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Finerenone and esaxerenone protected against chronic dysfunction and fibrosis induced by different models of CKD by reducing TGF- hyperexpression, inhibiting M1 MMT and facilitating macrophage polarization to an M2 phenotype by increasing macrophage IL-4 receptor expression and activation [198, 199]

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However, when the intestinal barrier is compromised (often referred to as leaky gut), this critical function is disrupted

ROS are also continuously generated by enzymatic reactions involving cyclooxygenases, NADPH oxidases (NOXs), xanthine oxidases and lipoxygenases and through the iron-catalyzed Fenton reaction

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