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doi: 10.1152/ajprenal.00384.2005

Overall, these results clearly suggest that circadian regulation of cellular dynamics in tumors can dictate the time-of-day specificity of anticancer drugs (Fig

To view or add a comment, sign in Disease biology matters: our latest study compares two closely related CD28-costimulated anti-CD19 CAR T-cell products across autoimmune diseases and aggressive B-cell lymphoma

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GT-activated prodrugs and potential nephrotoxicity Gamma-glutamyl transferase being the initial and limiting step in GT-activated prodrugs processing and because GT is highly expressed on the luminal surface of the proximal tubules in the kidney, potential nephrotoxicity could have been a limitation in the usage of this class of compound when administered systematically