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The tirzepatide to semaglutide transition typically involves starting semaglutide at a moderate dose (0.5mg or 1.0mg weekly) rather than the standard 0.25mg starting dose, since the body is already adapted to GLP-1 receptor activation

B., Groeneveld, P

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Whilst there was a reduction in systolic and diastolic blood pressure in all groups, this was only significant from baseline in the group who received the standard triple therapy and broccoli sprout powder combination (14 and 9.4 mmHg reduction in systolic and diastolic blood pressure, respectively) (Mirmiran et al., 2014)