MC-Val-Cit-PAB(m-PEG8)-Exatecan m-peg4 [O-]C(=O)C1=CC(=CC=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)C(=O)NCC#C Purity (HPLC): ≥ 95%

[O-]C(=O)C1=CC(=CC=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)C(=O)NCC#C Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

5-FAM azide is an excellent alkyne-reactive fluorescent reagent for labeling azide-containing biological molecules through click chemitry

324 SMILES CC(C)(C)OC(=O)N1CCN(CCN)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name tert-butyl N-{2-[2-(piperazin-1-yl)ethoxy]ethyl}carbamate Synonyms CAS Number n/a Related CAS Molecular Formula C13H27N3O3 Molecular Weight 273

Product Name Pomalidomide-CO-C4-alkyne Synonyms Pomalidomide-4'-CO-C4-alkyne CAS Number n/a Related CAS Molecular Formula C20H19N3O5 Molecular Weight 381

MC-Val-Cit-PAB(m-PEG8)-Exatecan m-peg4 [O-]C(=O)C1=CC(=CC=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)C(=O)NCC#C Purity (HPLC): ≥ 95%SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures,