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Upon the entry of blood-borne pathogenic antigens into the peri-ellipsoidal lymphoid sheaths of the chicken spleen, Toll-like receptors on ellipsoid-associated cells first recognize pathogen-associated molecular patterns (58, 59), triggering intracellular signaling cascades such as the NF-B pathway, thereby activating ellipsoid-associated cells and upregulating the expression of phagocytosis-related receptors

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