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The percentage of subjects receiving OCA 25 mg that achieved the primary endpoint was 23.8% among those with baseline GLP-1 RA use, 21.6% of those who added a GLP-1 RA, and 22.4% in the overall ITT population, compared to 4.3%, 7.5%, and 9.6% receiving placebo, respectively (Figure 1)

IAP activity was measured in stool and ileal content of young (4-month-old) and old (21-month-old) WT C57BL/6J mice by IAP assay

This may help improve skin elasticity, hydration, and overall skin quality, which can become more noticeable as estrogen levels decline during midlife

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Please consult your healthcare practitioner before use, especially if you are pregnant or nursing, to make an informed decision towards enhancing your well-being.