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In contrast, the amount of ceramide (Cer) contained in the liver of PTEN KO was generally higher than that of wild-type mice, especially d18:1/22:0 and d18:1/22:0, which were more than twice that of wild-type mice

Recent studies have also identified microbial-host co-metabolites that link gut dysbiosis to sleep and aging

This pathway involves functionalizing PLGA nanoparticles with ligands that specifically bind to receptors highly expressed on the endothelial cells of the brain, including transferrin, lactoferrin, insulin, and low-density lipoprotein receptors