Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-MMAE protac ligand making it a powerful tool

making it a powerful tool for monitoring SARM1 activation in biochemical assays

Product Name Mal-Lys(m-PEG4)-Val-Cit-PAB Synonyms CAS Number Related CAS Molecular Formula C38H59N7O12 Molecular Weight 805

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The water soluble 5(6)-TAMRA PEG3 azide has a long PEG3 spacer that separates the dye tetramethylrhodamine (commonly known as TMR or TAMRA) from the terminal azide group

including high photostability

Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-MMAE protac ligand making it a powerful toolSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to