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Phosphorylation alters the electrostatic charge of its C-terminal domain, increasing its propensity for conformational changes, thus facilitating the transition from soluble monomers to insoluble oligomers and fibrils, effectively acting as a catalyst for the protein aggregation cascade [52]

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In vitro and animal studies have found that lipoic acid exhibits immunomodulatory properties through mechanisms that stimulate the production of cyclic AMP (cAMP) (90, 91) a central regulator of innate immune functions and inhibits the migration of immune cells into the brain and spinal cord (92), possibly by decreasing endothelial expression of cell adhesion molecules, inhibiting expression of enzymes like matrix metalloproteinases (MMP), and/or reducing the permeability of the blood-brain barrier (87, 89, 93, 94)

As limitaes atuais da pesquisa incluem a ausncia de ensaios clnicos randomizados de grande porte em humanos, uma compreenso ainda parcial dos mecanismos moleculares precisos e uma carncia de dados farmacocinticos detalhados em humanos

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