DBCO-Propionyl-Val-Cit-PAB(m-PEG8)-Exatecan building block Wolstenholme

Wolstenholme

S)-AHPC-CO-C5-OH Synonyms CAS Number n/a Related CAS Molecular Formula C28H40N4O5S Molecular Weight 544

This probe is also ef

366 SMILES OCCOCCCC1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Kirkpatrick

DBCO-Propionyl-Val-Cit-PAB(m-PEG8)-Exatecan building block WolstenholmeSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC