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The first (classical) pathway is as follows: under normal conditions Nrf2 is localized in cytoplasm and associated with its inhibitor KEAP1 (Kelch-like ECH (Nrf2)-associated protein-1), which stimulates Nrf2 ubiquitinylation and its subsequent proteasomal degradation

5-(Diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide: a new efficient phosphorylated nitrone for the in vitro and in vivo spin trapping of oxygen-centered radicals

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