Azide-Propionyl-Val-Cit-PAB(m-PEG8)-Exatecan Size:5mg E7820 induce targeted degradation of

E7820 induce targeted degradation of the splicing factor RBM39 through recruitment of the E3 ubiquitin ligase CRL4DCAF15

Product Name Mal-Propionyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-MMAE Synonyms CAS Number Related CAS Molecular Formula C88H142N14O26 Molecular Weight 1812

hydroxyethoxy)

483 Purity (HPLC) >= 95% Solubility DMSO

917 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCCCCC#C)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Azide-Propionyl-Val-Cit-PAB(m-PEG8)-Exatecan Size:5mg E7820 induce targeted degradation ofSOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC