Mal-Acetyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8) peg6 Contains an E3 ligase ligand

Contains an E3 ligase ligand with PEG linker and terminal amine

Product Name Thalidomide-5'-O-PEG1-C2-acid Synonyms CAS Number n/a Related CAS Molecular Formula C18H18N2O8 Molecular Weight 390

684 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC=C(C=C2C([O-])=O)C(=O)NCCOCCOCCOCC#C)=[N+](C)C)=C1

242 SMILES OC(=O)C1=CC=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name Pomalidomide-C5-acid Synonyms Pomalidomide-4'-C5-acid CAS Number 2225940-49-6 Related CAS Molecular Formula C19H21N3O6 Molecular Weight 387

Mal-Acetyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8) peg6 Contains an E3 ligase ligandSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Acetyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Acetyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. Derived from established