DBCO-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan dbco-lys-m-PEG4 Product Name MC-Val-Cit-PAB-PNP Synonyms MC-VC-PAB-PNP

Product Name MC-Val-Cit-PAB-PNP Synonyms MC-VC-PAB-PNP

92 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCOCCOCCO)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Derived from established ADC linker architectures

RSC Medicinal Chemistry

ZXH-1-161 is a potent cereblon (CRBN) modulator with an IC50 value of 39 nM in MM1

DBCO-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-Exatecan dbco-lys-m-PEG4 Product Name MC-Val-Cit-PAB-PNP Synonyms MC-VC-PAB-PNPSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a DBCO Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further