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Inositol trisphosphate (IP 3 )/Ca 2+ signaling in astrocytes controls theta rhythm and REM sleep, and genetically lowering IP 3 levels in astrocytes was reported to solely affect REM sleep (Foley et al., 2017)

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The mechanism of action may be through the regulation of FeNO and 25(OH)D levels, downregulating inflammatory factors, thereby reducing the degree of inflammation (164)

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It is not obvious that the methionine cycle would need to be supported by a biochemical like glutathione, whose formation is considered to be dependent on the function of the methionine cycle