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Studies indicate that graduated concentration protocols, beginning with lower concentrations and increasing based on tolerance, optimize both safety and efficacy outcomes

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Schmeisser K, Mansfeld J, Kuhlow D, Weimer S, Priebe S, Heiland I, Birringer M, Groth M, Segref A, Kanfi Y (2013) Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

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