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The majority of the oxidative stress markers are generated during lipid metabolism and might be associated with aberrant metabolism in psoriasis (Cannavo et al., 2019)

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Consistently, it has been found to bind to REV-ERBs in a redox-state dependent manner 76 to NPAS2, a CLOCK paralog, thereby modulating its DNA binding activity, as well as to inhibit binding of CLOCK to its E-box DNA target 77

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