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The combination of reduced supportive cues and overactive VEGF-mediated signaling produces leaky, structurally abnormal microvessels that exacerbate BBB breakdown, microvascular degeneration, and neuronal vulnerability, highlighting astrocytes as critical modulators of neurovascular health and promising therapeutic targets in PD

The concentration of purified At LDOX was measured with a NanoDrop spectrophotometer (Thermo Fisher Scientific) at A 280nm using an extinction coefficient estimated with ProtParam 50

Increased kidney xanthine oxidoreductase activity in salt-induced experimental hypertension

For the sample preparation, 150 L of freshly prepared aqua regia (HCl:HNO 3 = 3:1) was added to 50 L of the sample, and the mixture were kept in an auto-shaker for overnight at room temperature

Current Neuropharmacology, 19 (8), 12021224

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