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Despite their benefits, due to the technical challenges of the surgical procedure, the high cost, and outcomes similar to spinal fusion, total IVD disc replacements are not yet widely used (Phillips et al., 2015)

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His decision to do so was helped by his realisation that 'Jerne would be a wonderful teacher' and provided scope 'to ask stupid questions' (Lefkovits 2025)

Treatments with DSIP and DSIP-CBBBP are shown to effectively increase melatonin levels, indicating a stress-mitigating potential, whereas CBBBP treatment alone does not significantly affect melatonin levels, pointing to its limited efficacy in this context