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preliminary or emerging evidence applies to off-label longevity contexts

10.1017/S1041610211000974 Int

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It can take months and years for patients with diabetes taking the drug to begin noticing symptoms of a B12 deficiency

10.1016/j.survophthal.2020.01.002 10

It is the downstream output of a finely calibrated feedback loop that begins roughly at the base of the brain