Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan Size:5mg 438 SMILES [N-]=[N+]=NCCOCCOCCNC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)

438 SMILES [N-]=[N+]=NCCOCCOCCNC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

252 SMILES BrCCCC(=O)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

17515–17523

TMP3-TMR is a third-generation covalent TMP-tag designed for improved efficiency in protein labeling and interaction studies

031 Purity (HPLC) >= 95% Solubility DMSO

Mal-Lys(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan Size:5mg 438 SMILES [N-]=[N+]=NCCOCCOCCNC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by