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Participants with renal impairment were excluded if they had previously undergone renal transplantation or had unstable renal function or acute exacerbation of renal disease within 14 days of baseline, as indicated by recent history or worsening of clinical or laboratory signs

& Li, G

10.1016/s0140-6736(16)32453-32459 Lancet 15 BuurmanR.GurlevikE.SchafferV.EilersM.SandbotheM.KreipeH.et al (2012)

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A substudy of the ENGAGE AF-TIMI 48 trial revealed that 2740 of the 14,071 patients who received either warfarin or the high-dose edoxaban regimen (HDER