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Studies had shown that smoking increases conduction velocities, and decreases effective refractory period by decreasing parasympathetic tone in atrial conduction system and also increases sympathetic tone which could be responsible for the excess SVEs.12 Smoking also increased ventricular arrhythmias, but this increase did not reach statistical significance

A year later, the factory and its 12 workers had produced 150,000 pounds of southern flat plug chewing tobacco

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10.1001/jama.291.10.1238 Danaei G, Ding EL, Mozaffarian D, Taylor B, Rehm J, Murray CJL, Ezzati M: The Preventable causes of death in the United States: comparative risk assessment of dietary, lifestyle, and metabolic risk factors