Mal-Propionyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan adc Complimentary to 5-FAM isomer

Complimentary to 5-FAM isomer

a novel and potent GSPT1 degrader displaying selectivity over 9000 proteins

Product Name: Cy3 carboxylic acid monosulfo Synonyms: Cy3 carboxylic acid

378 SMILES O=C(CCCC#C)NC1=CC=C2C(=O)N(CC2=C1)C1CCC(=O)NC1=O Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

4-diethylamine 4HCl CAS Number 852392-58-6 Related CAS 6531-38-0 Molecular Formula C8H24Cl4N4 Molecular Weight 318

Mal-Propionyl-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-Exatecan adc Complimentary to 5-FAM isomerSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Mal Propionyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The payload is