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[DOI] [PMC free article] [PubMed] [Google Scholar] 22.Chu C., Deng J., Man Y., Qu Y

Kuhns L, Kroon E, Lesscher H, Mies G, Cousijn J (2022) Age-related differences in the effect of chronic alcohol on cognition and the brain: a systematic review

3.2.3 Downregulate expression of NF-B and upregulate expression of Nrf-2 NF-B regulated inflammatory responses and its activation lead to increased expression of pro-inflammatory cytokines, while nuclear factor-erythroid 2related factor 2 (Nrf-2) reduced the synthesis of inflammatory mediators by inhibiting the NF-B (Thimmulappa et al., 2016)

During stressful periods, the body often sends clear signals that are tolerated for a long time in everyday life