Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG4)-PNP Size:100mg Rational discovery of molecular glue

Rational discovery of molecular glue degraders via scalable chemical profiling

Norbornene-CA CAS Number Related CAS Molecular Formula C18H30ClNO3 Molecular Weight 343

Cy3 can be used in combination with other fluorescent dyes (e

Product Name BG-MaP555 Synonyms MaP555-SNAP CAS Number 2434651-49-5 Related CAS Molecular Formula C40H40N10O6S Molecular Weight 788

Product Name Pomalidomide-C3-amine HCl Synonyms Pomalidomide-4'-C3-amine HCl CAS Number 2154342-45-5 Related CAS 2093388-20-4 (free base) Molecular Formula C16H19ClN4O4 Molecular Weight 366

Mal-Propionyl-PEG2-Val-Cit-PAB(m-PEG4)-PNP Size:100mg Rational discovery of molecular glueSOLU KNEX cleavable linker features a Val Cit dipeptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The PNP (para nitrophenyl) moiety serves as an activating