Azide-Hexanoyl-Val-Cit-PAB(m-PEG8)-Exatecan cit SulfoCy3(Sulfo-Cyanine3

SulfoCy3(Sulfo-Cyanine3

NBD-TM is a thiomorpholine-based fluorogenic probe for HOCl

Product Name DOTA-PEG5 Synonyms CAS Number n/a Related CAS Molecular Formula C26H49N5O12 Molecular Weight 623

Bioconjugate Chemistry

NCCCC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Azide-Hexanoyl-Val-Cit-PAB(m-PEG8)-Exatecan cit SulfoCy3(Sulfo-Cyanine3SOLU KNEX cleavable linker features a Val Cit dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC