Azide-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-PNP Size:100mg 279 SMILES BrCCCCC(=O)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)

279 SMILES BrCCCCC(=O)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

281 SMILES BrCCCCCC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

HQ461-mediated degradation of cyclin K impairs CDK12 function

Product Name Trametiglue Synonyms CAS Number 2666940-97-0 Related CAS Molecular Formula C25H24FIN6O5S Molecular Weight 666

Product Name Phthalimidinoglutarimide-5'-propargyl-PEG2-OH Synonyms CAS Number n/a Related CAS Molecular Formula C20H22N2O6 Molecular Weight 386

Azide-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-PNP Size:100mg 279 SMILES BrCCCCC(=O)NC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Azide Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The azide functional group is widely utilized in bioconjugation via click chemistry to enable efficient and selective attachment of biomolecules. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase