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Also, this pathway has cellular effects as silencing of the G6PD enzymethe first and rate-limiting enzyme of the PPP reduces EC proliferation and migration while increasing intracellular ROS (Leopold et al., 2003)

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doi: 10.1007/s40265-016-0599-7

There are other brain-related disorders and conditions that also share these mechanisms, including spinal cord injury, traumatic brain injury, diabetes-induced cognitive decline, depression, and anxiety

We generated three distinct mouse embryonic stem cell lines: a complete Mettl9 knock-out (KO), an inducible METTL9 Degron and a line endogenously expressing a catalytically inactive protein, and assessed their ability to undergo neural differentiation

10.1016/S1525-1578(10)60003-7 J