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A large multi-ethnic cohort of healthcare members focused on an even later window of smoking exposure, 15 midlife to late-life, and found that heavy smoking in midlife and late-life more than doubled the risk of late-life dementia

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95 Moreover, oxidative stress can alter histone acetylation/deacetylation processes, allowing transcription factors to access DNA and start inflammatory gene transcription (discussed below)

In fact, nicotine addiction is considered more challenging to overcome than addictions to alcohol, cocaine, and even heroin, primarily due to the accessibility and social acceptance of cigarettes