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Note: Not for sale to minors

Retrieved 10 October 2022

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Clinically, this white lesion was referred to as leukoplakia until the microscopic examination revealed severe epithelial dysplasia (a disorganized growth that is considered premalignant) throughout the epithelium with no invasion of abnormal cells past the basement membrane

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At the end of the study, 332 patients (12%) had COPD GOLD stage II or higher