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We hypothesized that studies presenting statistically significant outcomes are more likely to be published, even when they have small sample sizes, potentially leading to asymmetry in the funnel plot

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In tobacco, two compounds of concern are 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), which is derived from nitrosation of nicotine, and N-nitrosonornicotine (NNN), which is derived from nitrosation of nornicotine

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