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High doses can lead to seizures, coma, and even death

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In fact, evidence from the animal literature suggests that ALLO fluctuation can modify the GABA A receptor subunit composition such that ALLO has a paradoxical effect at the GABA A receptor [24]in other words, ALLO inhibits GABAergic transmission rather than enhances it

Meanwhile, bidis, which are subject to a 28 per cent GST, have been left unaffected