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7 TAM secretes cytokines that include CCL18, matrix metalloproteinases (MMPs), and vascular endothelial growth factor A (VEGF-A), which stimulate tumor migration, angiogenesis, and metastasis

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The rates themselves are percentages calculated by dividing the estimated number of smuggled cigarettes by the state's estimated total consumption of cigarettes (both legally and illegally purchased).[] The first output we examined from our model involves average casual and commercial smuggling rates for 47 of the 48 contiguous states from 1990 through 2006

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