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Although previous studies have used VBM based on the analysis of regions of interest (ROIs) to explore the changes caused by chronic cigarette smoking to some extent, this method excludes some key regions [5], [8]

A more thorough understanding of the step-wise conversion of precarcinogens to carcinogens, binding of carcinogens to DNA, mutation of DNA, DNA repair, and cellular destruction of carcinogens should contribute to the design of drugs that can modify these processes

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However, at high battery voltages, aldehyde emissions are closer to and could even exceed those generated by cigarettes [41]

The End of an Era the commentary At the end of The End of an Era is it possible were finally getting an answer to *the* question