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17 Furthermore, in a model of inhalational tolerance, prolonged cigarette smoke exposure of mice significantly delayed the establishment of tolerance induced by repeated harmless antigen challenges

The efficiency and integrity of the lung structure, phagocytes and mucociliary clearance are crucial, as an impairment in the function and structure can lead to respiratory conditions such as asthma, COPD and cystic fibrosis (Munkholm and Mortensen 2014)

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The bodys ability to repair blood vessels is a key factor here

doi: 10.1371/journal.pone.0121200