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Former smokers had a 1.14 times higher risk than nonsmokers of having epilepsy, but this difference didnt reach statistical significance.In a 2019 study, researchers found that smokers with epilepsy were nearly 4 times more likely to experience seizures in the past year than nonsmokers.In a 2020 report by the Centers for Disease Control and Prevention (CDC), researchers reported higher rates of smoking in people with epilepsy versus people without a history of epilepsy: 24.9% of people with active epilepsy were smokers 25.9% of people with inactive epilepsy were smokers 16.6% of people with no history of epilepsy were smokers Chemicals found in cigarette smoke may also decrease the effectiveness of certain epilepsy medications that control seizures