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These data indicate the implication of PSPH in the regulation of the aggressive and immunosuppressive tumor microenvironment in GBM, which could be targeted by sertraline/chloroquine combination treatment

4e,f and Extended data Table 3)

Blood plasma/serum samples are easily accessible clinically and allow to investigate the metabolic changes in patients with cancer and in response to cancer treatments

Ferroptosis can be experimentally induced by direct inhibition of Gpx4 via Ras-selective lethal small molecule 3 (RSL3) or by genetic knockdown or deletion of Gpx4 (Yang et al., 2014)

Natural inhibitors of angiogenesis Figure-4: Natural health products inhibiting VEGF: Targeting angiogenesis by VEGF blockers may be an effective strategy to increase the efficacy of immunotherapy by improving effector T-cells function whereas decreasing the number and efficacy of immunosuppressive cells in the TME

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