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Past studies have suggested that these products, along with hookah waterpipes, expose the respiratory system to higher levels of nicotine, carbon monoxide, and other toxic chemicals than traditional cigarettes and cigars

found that mitochondrial uncoupler carbonyl cyanide 3-chlorophenylhydrazone (CCCP) mediated the PINK1-Parkin pathway in neuroblastoma SH-SY5Y cells to promote the translocation of TFEB to the nucleus, elevating P62 expression and enhancing mitophagy

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This method avoids crushing the wrapper, prevents tar buildup, and minimizes odor

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