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In methamphetamine dependence, results of a 12-week RCT (N=229) using sertraline 100 mg/d vs placebo (+/- contingency management) led the authors to deem sertraline contraindicated . 16 An increased propensity to relapse after completing 6 weeks of treatment in the sertraline groups (13/61) vs placebo (5/68) appeared to relate to sustained craving for methamphetamine

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Nicotine and the Brains Reward Circuit Nicotine (NCT), the primary psychoactive compound in tobacco, has a deceptively simple structure composed of a pyridine and a pyrrolidine ring (Figure 1)

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Secondly, smoking (nicotine) might contribute to deteriorating mental health through neurotransmitter pathways