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This again is based on a different endpoint (increase of blood pressure in this case, which is expected to be more sensitive than mortality)

participants of wave 4 (2010) and wave 5 (2011) were more likely to be less educated and to have a higher household income than participants of wave 3 (2008)

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For example, it is known that the nicotinic cholinergic receptors become desensitized after one or two cigarettes

Overall tobacco use among adults increased in 2022, driven by a rise in e-cigarette use from 4.5% to 6%

In addition, we did not study the effect of varenicline per se , but rather the effect of a method of drug administration