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Most Addictive Substances Ranked Smoking Information and Tips for Quitting The 10 Most Addictive Substances on Earth Rehab Spot Nicotine is a gateway drug NW NOGGIN: Neuroscience outreach group (growing in networks) What is the Most Addictive Drug in the World? The nicotine in tobacco is a highly addictive substance that makes people dependent on the product. This is dangerous because tobacco use is a major risk factor for many cardiovascular and respiratory
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