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Although p53 induced apoptosis via PUMA and NOXA and cell senescence via p21 play critical roles in preventing cells from malignant transformation, these two mechanisms are dispensable for p53-mediated suppression of spontaneous tumour development

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1 Also, there is a strong ethical case for providing excellent cessation support, given that most smokers desperately want to quit, and smoking is increasingly denormalised and may result in stigma