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Many people who suffer with heart disease state that they experience a vague discomfort as well as the following: Pressure, fullness, burning or tightness in your chest Crushing or searing pain that radiates to your back, neck, jaw, shoulders, and one or both arms Pain that lasts more than a few minutes, gets worse with activity, goes away and comes back, or varies in intensity Shortness of breath Cold sweats Dizziness or weakness Nausea or vomiting