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In addition, DCs are potent producers of the IL-12 cytokine family member, IL-23 (or IL-17E), which is necessary to maintain the Th17 phenotype and represents a strong activator of Th17 effector function

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But perhaps the biggest reason that cigarette sales in Wisconsin dropped so much has to do with taxing: "...one likely contributor that stands out in Wisconsin is the multiple, significant tax rate increases the state put in place in 2002, 2008, and 2009." So what's the problem, then